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HAVE A QUESTION? > Proline in gluten vs. broth

I have read that proline cannot be broken down in gluten because we do not have the enzymes to break it down, and therefore that is causing damage to our gut. Then, I also read that proline- rich broth is gut healing. Are we talking about two different things?
December 14, 2013 | Unregistered CommenterInpired RN
That is a great question,Inspired RN and it is a confusing concept. I will work to get a MUCH better answer for you (hoping I can get it directly from Dr. Fasano), but my understanding is that it is the form it takes and how it is binding - like glutamine, which is another amino acid gut healer, which is different than the gluten. Here are a few articles that discuss this.

The interview that is being quoted:

A description of amino acids:

A description of glutamine from the University of Maryland Medical School (did not find one for proline):

Main chain hydrogen bond interactions in the binding of proline-rich gluten peptides to the celiac disease-associated HLA-DQ2 molecule.:

So what is the answer to this question? I think gluten have proline but it is binded to other amino acids while in broth there may be free proline - it is digested by cooking?
If this is not true than broth is the same as gluten - not digestible for some people?

June 15, 2018 | Unregistered Commenterpesho